George Clooney is the nephew of singer and actress Rosemary Clooney and the son of TV host Nick Clooney.
He made his acting debut in television in 1978, appearing in a short-lived sitcom called 'E/R,' not to be confused with his later role in 'ER.'
Clooney rose to fame with his role as Dr. Doug Ross on the television series 'ER,' which earned him two Primetime Emmy Award nominations.
He is one of the few actors to have won Academy Awards for both acting ('Syriana') and producing ('Argo').
George Clooney is known for his pranks on set, often playing elaborate jokes on his co-stars and friends.
In 2009, Time magazine named Clooney one of the 100 most influential people in the world.
He is a passionate humanitarian and co-founded the organization 'Not On Our Watch' with other celebrities to focus global attention on human rights violations.
George Clooney turned down the role of Jack in 'The Notebook,' which later went to Ryan Gosling.
He has a strong political voice and has been an outspoken advocate for issues like the Darfur conflict and the refugee crisis.
Clooney married human rights lawyer Amal Alamuddin in 2014, and the couple has two children, twins Ella and Alexander.
He is a co-owner of the tequila brand Casamigos, which he and his partners sold to Diageo for $1 billion in 2017.
George Clooney is known for his love of motorcycles and has been riding since he was a teenager.
He played Batman in the 1997 film 'Batman & Robin,' a role he has since jokingly apologized for.
Clooney is a two-time recipient of the Golden Globe Award for Best Actor for his performances in 'O Brother, Where Art Thou?' and 'The Descendants.'
He is known for his close friendship with actor Brad Pitt, with whom he has starred in several films, including the 'Ocean's' trilogy.